Medroxyprogesterone acetate

Information About Medroxyprogesterone acetate

Uses of Medroxyprogesterone acetate

Medroxyprogesterone acetate is commonly used in the treatment of abnormal uterine bleeding, breast cancer, endometriosis and post menopausal osteoporosis. it is also used to relieve heavy menstrual bleeding. medroxyprogesterone acetate is also used in hormone replacement therapy and contraception.

How Medroxyprogesterone acetate Works

Medroxyprogesterone Acetate is a synthetic form of progesterone which converts the proliferative phase of the endometrium into secretory phase but without the presence of estrogenic activity and minimal androgenic effect.

Side Effects of Medroxyprogesterone acetate

Dysfunctional uterine bleeding (irregular menstrual cycle, spotting, ) Fatigue, Insomnia, Edema, Depression, Dizziness, Headache, Nausea, Vomiting, Breast tenderness, Weight gain or loss, Pain at injection site

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Medroxyprogesterone acetate Related Warnings

Alcohol Not Advisable

Alcohol will be an added risk of low bone mineral density with simultaneous use of Medroxyprogesterone acetate. Taking Medroxyprogesterone Acetate with alcohol may alaso interfere with the absorption and metabolism of Medroxyprogesterone acetate.

Pregnancy Not Safe - High Risk

Medroxyprogesterone Acetate is contraindicated to use during pregnancy. Both animals and human studies have proven adverse effects on the fetus. The risks clearly outweigh the benefits of Medroxyprogesterone Acetate. Please consult your doctor if pregnancy occurs.

Lactation Safe If Prescribed

Tablet: Medroxyprogesterone Acetate and its metabolites are can pass into breast milk but risk to baby is minimal. Please consult your doctor. Injection: No adverse effects have been noted to child exposed to Medroxyprogesterone Acetate, even though it can be secreted in breast milk.

Driving Generally Safe

Medroxyprogesterone acetate usually does not affect the ability to drive. Do not drive unless you are feeling well.

Kidney Safe If Prescribed

Dose adjustment of Medroxyprogesterone Acetate is not needed since it is eliminated by hepatic metabolism.

Liver Safe If Prescribed

Medroxyprogesterone Acetate is contraindicated in patients with severe hepatic impairment. It should be used with caution in patients with any other liver disease. Dose adjustment of Medroxyprogesterone Acetate may be needed. Please consult your doctor.