Probenecid

Information About Probenecid

Uses of Probenecid

Probenecid is commonly used in the treatment of gout

How Probenecid Works

Probenecid is a medication to increase uric acid excretion. Probenecid works by inhibiting competitively the reabsorption of uric acid at the proximal convoluted tubules of the kidney causing an increase in excretion of uric acid & reduction in serum uric acid level concomitantly.

Side Effects of Probenecid

Nausea, vomiting, anorexia, headache, sore gums, flushing, alopecia, dizziness, anaemia, urinary frequency, hypersensitivity

Authorship

Written By

Dr Sri Viknarajan

MD (Universiti Hasanuddin, Indonesia)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Probenecid Related Warnings

Alcohol Not Advisable

Drinking too much alcohol may increase the amount of uric acid in the blood and lessen the effects of this medicine.

Pregnancy Maybe Safe

Probenecid crosses the placenta barrier and appears in cord blood. The use of any drug in women of child bearing potential requires that the anticipated benefit be weighed against possible hazards.

Lactation Limited Data

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Driving Generally Safe

Probenecid usually does not affect the ability to drive. Do not drive unless you are feeling well.

Kidney Use With Care

When you first begin taking probenecid, the amount of uric acid in the kidneys is greatly increased. This may cause kidney stones or other kidney problems in some people. The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor of existing kidney disease.

Liver Limited Data

There are no reports on the frequency of liver test abnormalities during probenecid therapy, but they are probably rare as Probenecid is largely secreted unchanged in the urine.