Salbutamol

Information About Salbutamol

Uses of Salbutamol

Salbutamol/albuterol is commonly used in the treatment of asthma and chronic obstructive pulmonary disease (copd).

How Salbutamol Works

Salbutamol activates the enzyme that stimulates the production of cAMP. It leads to the activation of protein kinase A, which lowers intracellular ionic Ca concentration and inhibits phosphorylation of myosin. This relaxes the smooth muscle in the airways which relief breathlessness.

Side Effects of Salbutamol

Tremor, Nausea and vomiting, Palpitations, Chest discomfort, Tremors, Dizziness, Headache, Sweating, Hypersensitivity reaction

Authorship

Written By

Dr Sri Viknarajan

MD (Universiti Hasanuddin, Indonesia)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Salbutamol Related Warnings

Alcohol Not Advisable

It is unsafe to consume alcohol with Salbutamol. Taking Salbutamol with alcohol may worsen the side effects such as headache, dizziness, lightheadedness, fainting, and/or palpitations.

Pregnancy Not Safe

Salbutamol may be unsafe to use during pregnancy. Animal studies have shown adverse reactions on the fetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable even with the risk. Please consult your doctor.

Lactation Limited Data

Salbutamol excretes in breast milk but it is not known to show any harmful effect on breastfed babies. However, its usage should be restricted unless the benefits outweigh the risks.

Driving Generally Safe

Salbutamol usually does not affect the ability to drive. Do not drive unless you are feeling well.

Kidney Use With Care

Salbutamol should be used with caution in patients with severe kidney disease as it may cause hypokalaemia. Dose adjustment of Salbutamol may be needed. Please consult your doctor.

Liver Limited Data

Salbutamol should be safe to use in patients with liver disease. It is rare for most of the antiasthmatic agents to cause hepatotoxicity. No dose adjustment of Salbutamol may be needed.