Metoclopramide

Information About Metoclopramide

Uses of Metoclopramide

Metoclopramide is commonly used in the treatment of heartburn, indigestion, nausea and vomiting

How Metoclopramide Works

Metoclopramide exerts its antiemetic action by acting on the dopamine and serotonin receptors in the chemoreceptor trigger zone of the central nervous system, also known as the vomiting centre. It causes an increase in response to acetylcholine in the upper gastrointestinal tract thereby increasing the gastric emptying time and intestinal transit time without affecting the gastric, biliary and pancreatic secretions.

Side Effects of Metoclopramide

Diarrhea, Asthenia, Somnolence, Depression, Galactorrhoea, Parkinson symptoms

Authorship

Written By

Dr Sri Viknarajan

MD (Universiti Hasanuddin, Indonesia)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Metoclopramide Related Warnings

Alcohol Not Advisable

It is unsafe to consume alcohol with Metoclopramide as alcohol potentiate sedative effect of Metoclopramide.

Pregnancy Maybe Safe

Metoclopramide may be unsafe to use during pregnancy. Animal studies have not shown adverse effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may outweigh the risk. Please consult your doctor before using.

Lactation Limited Data

It is found that Metoclopramide is excreted in minimal quantities in breast milk and not adequate to cause harmful effects. However, it is advisable to practice caution while taking Metoclopramide during breastfeeding.

Driving Not advisable

Do not drive unless you are feeling well. Metoclopramide may cause side effects such as dizziness, drowsiness or abnormal muscle twitching, all of which could affect the ability to concentrate and drive.

Kidney Use With Care

Metoclopramide dose should be adjusted in patients with renal impairment..

Liver Limited Data

Metoclopramide should be cautionly use in patients with liver problem. Dose adjustment is advisable in this group of people.