Buy Xigduo XR 10/1000mg Tablet 28s- Uses, Dosage, Side Effects, Instructions

How To Use Xigduo XR 10/1000mg Tablet 28s

This medicine is for oral use only. Swallow this medication as a whole with water. Do not chew, crush or break it. It is better to take this medication at a fixed time each day if it is indicated for everyday use.

Brands

AstraZeneca

Active Ingredient

dapagliflozin metformin

Manufactured by

AstraZeneca Pharmaceuticals LP

Side Effects

As with all medications, you may experience some side effects. Not everyone experiences it. This is not a cause for concern. However, it is so that you are aware of it.

There could be certain side-effects associated with the usage of the medication. Please refer to the list below:-

Renal impairment
decreased creatinine clearance
increased blood pressure
Urinary tract infection
vulvovaginal mycotic infection

While some these symptoms are more common, there are a few rare symptoms that could also occur. If you are feeling any other symptoms (whether it is mentioned in the above list or not), please consult with a doctor immediately. Please, consult with a doctor if you are having rashes or blurry visions. Report if you experience any other symptoms as the above list may not be exhaustive. These symptoms become more prominent as when one is undergoing a long term therapy with this medication.

Nausea, Constipation, Thirst, Dry mouth, Back pain, Dizziness, Urticaria, Hypoglycemia, Dysuria, Rash, Vaginitis/balanitis, Urinary Tract Infection

Cough or hoarseness, Decreased appetite, Diarrhea, Dyspnea, Upper respiratory tract infection, Nausea, Vomiting, Flatulence, Heartburn/dyspepsia, Abdominal distention, Constipation.

Warning Precautions

Precautionary Steps of Xigduo XR 10/1000mg Tablet 28s

Please consult a doctor especially before taking Xigduo XR. If you have or experiences any of the following conditions & contraindications:-

Allergy to Xigduo XR or any of its components
It is not recommended for children & Neonates. Please keep Xigduo XR out of reach from them.
Hypersensitivity
Diabetic ketoacidosis
Dehydration
severe infection
pulmonary embolism
recent MI
hepatic impairment
acute alcohol intoxication
Moderate or severe renal impairment
Pregnancy
Lactation

Please stop using this medication if you are experiencing these symptoms and conditions.

Xigduo XR Drug Interactions

Drug to drug interaction reaction of Xigduo XR varies from a person to another person. It is advisable to check with your doctor about all the possible drug interactions before starting the medication.

Metformin
Digoxin
Morphine
Procainamide
Vancomycin
Frusemide
Corticosteroids
thyroid products
Oral contraceptives
Phenytoin
Ca-channel blocking drugs

This is an incomprehensive list of drug-to-drug interactions and conditions that might interfere with Xigduo XR function. Do inform your doctor about all your current medications prior to consuming this drug.

Keep the following precautions in mind as well:-

Avoid Xigduo XR from excess exposure to sunlight
Avoid this medicine for a longer use
Alcohol might affect your liver if it is taken with this medication
Tell your doctor if you have any other diseases or if you are taking any other medication
Do not discontinue the prescribed course

Alcohol Warning (Not Advisable)

There is no known interaction of Xigduo XR 10/1000mg Tablet 28s with alcohol.It is unsafe to consume alcohol with Xigduo XR 10/1000mg Tablet 28s. Alcohol intoxication can increase the risk of lactic acidosis particularly in case of fasting, malnutrition or hepatic impairment.

Pregnancy Warning (Not Safe)

Xigduo XR 10/1000mg Tablet 28s may be unsafe to use during pregnancy. Animal reproduction studies have shown adverse effects on the fetus. However, there are limited well-controlled human studies. The benefits from the use of Xigduo XR 10/1000mg Tablet 28s in pregnant women may be acceptable despite the risk. Please consult your doctor. Xigduo XR 10/1000mg Tablet 28s should be safe to use during pregnancy because either animal or human studies have not shown any adverse effects on the fetus, however, uncontrolled hyperglycemia in people with PCOS can increase the risk of congenital abnormalities and intrauterine death.

Breastfeeding Warning (Not Advisable)

Xigduo XR 10/1000mg Tablet 28s is contraindicated during lactation. Animal studies have shown excretion of Xigduo XR 10/1000mg Tablet 28s in milk. Limited human studies suggest that Xigduo XR 10/1000mg Tablet 28s does not represent a significant risk to the baby when used during pregnancy. In regards to limited data, please consult your doctor to decide on discontinuation of breastfeeding or Xigduo XR 10/1000mg Tablet 28s.

Driving Warning (Generally Safe)

Xigduo XR 10/1000mg Tablet 28s usually does not affect the ability to drive. Do not drive unless you are feeling well.Xigduo XR 10/1000mg Tablet 28s usually does not affect the ability to drive. Do not drive unless you are feeling well.

Kidney Warning (High Risk)

Xigduo XR 10/1000mg Tablet 28s is contraindicated in patients with moderate to severe renal impairment and patients on dialysis. This is because the glycemic efficacy of the drug depends on renal function. Dose adjustment of Xigduo XR 10/1000mg Tablet 28s and monitoring of renal function is necessary. Please consult your doctor. Xigduo XR 10/1000mg Tablet 28s is not recommended in patients with severe kidney disease, especially in patients with creatinine clearance less than 60mL/min. Patients with severe kidney disease has high risk to get lactic acidosis. Dose adjustment of Xigduo XR 10/1000mg Tablet 28s and regular check up to monitor renal function may be needed. Please consult your doctor before consumption.

Liver Warning (Use With Care)

Xigduo XR 10/1000mg Tablet 28s should be used with caution in patients with severe liver impairment. Dose adjustment of Xigduo XR 10/1000mg Tablet 28s may be needed. Please consult your doctor.Xigduo XR 10/1000mg Tablet 28s should be used with caution in patients with liver disease due to increased risk of lactic acidosis. Hence liver function test should be done before initiating Xigduo XR 10/1000mg Tablet 28s. Discontinuation of Xigduo XR 10/1000mg Tablet 28s may be needed if there is deterioration of liver function. Please consult your doctor.

Quick Tips

You should try to exercise daily, follow a balanced diet, and take the other diabetes medications (if prescribed).
Take it with meal to prevent any stomach discomfort.
Xigduo XR may cause urinary tract infection. Drink a lot of water and practice good genital hygiene.
It can cause the body to be dehydrated or to have excessive urination. Drink lots of water to stay hydrated.
Keep sugary snacks and liquids in case you develop hypoglycemia symptoms such as cold sweats, cool pale skin, tremor, and anxiety.

FAQ

Does Xigduo XR 10/1000mg Tablet 28s cause hypoglycaemia?

Hypoglycaemia does not usually happen with Xigduo XR 10/1000mg Tablet 28s. However, it may occur when other glucose controlling medications are added to your therapy due to suboptimal control of your blood glucose levels.

Why does Xigduo XR 10/1000mg Tablet 28s increase the risk of developing genital and urinary tract infections?

Due to the way in which Xigduo XR 10/1000mg Tablet 28s works to lower your blood glucose levels, Xigduo XR 10/1000mg Tablet 28s provides a favourable environment for fungus to thrive and grow thereby resulting in genital infections developing. Xigduo XR 10/1000mg Tablet 28s also removes excess glucose by increasing the excretion of glucose into your urine which may lead to urinary tract infections. Therefore, it is advised that you increase your fluid intake and maintain good personal hygiene.

Does Xigduo XR 10/1000mg Tablet 28s cause weight gain?

No, instead Xigduo XR 10/1000mg Tablet 28s has been shown to cause modest weight loss in diabetic patients and individuals who are at risk for diabetes. However, do not start taking this medicine for weight loss on your own as Xigduo XR 10/1000mg Tablet 28s has not been approved to be taken solely for this reason. Consult your doctor or pharmacist before taking any kind of medication.

References

1. Dapagliflozin and metformin HCl extended-release. Wilmington, Delaware: AstraZeneca Pharmaceuticals LP; 2014 [revised Jul. 2017]. [Accessed 29 Apr. 2019] (online)

2. Medscape. Dapagliflozin+Metformin. [Accessed 25 Apr. 2019] (online)

3. Dapagliflozin + Metformin. Södertälje, Sweden: AstraZeneca; 2014. [Accessed 25 Apr. 2019] (online)

Xigduo XR 10/1000mg Tablet 28s

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